Heart Rate Variability Is Associated with Survival in Patients with Brain Metastasis: A Preliminary Report
Table 3
Prognostic factors for overall survival-univariate analysis and multivariate analysis.
Characteristics
Univariate analysis
Multivariate analysis
3M survival (%)
6M survival (%)
Median survival (M)
value
HR (95% CI)
value
Gender
0.711
0.604
Female
57.1
42.9
3.9
(—)
Male
47.4
35.5
2.0
Age
0.283
0.303
<65
54.2
45.8
3.9
(—)
≥65
50.0
29.2
2.6
Primary
0.160
0.333
NSCLC
54.2
48.5
3.7
(—)
Others
50.0
29.2
1.9
BM at diagnosis
0.996
0.775
No
50.0
36.7
2.3
(—)
Yes
56.3
37.5
3.7
KPS
0.002
0.022
<70
31.3
0.63
1.9
2.657 (1.153–6.123)
≥70
66.7
62.5
8.5
Reference
Extracranial metastasis
0.087
0.171
Without
71.4
57.1
21.4
(—)
With
48.5
36.4
2.6
Primary status
0.400
0.097
Not controlled
51.4
39.5
3.7
(—)
Controlled
60.0
40.0
3.9
SDNN (ms)
0.004
0.039
<10
30.8
15.4
1.8
2.204 (1.046–4.733)
≥10
63.0
51.4
8.0
Reference
RMSSD (ms)
0.100
0.868
<7
42.9
21.4
1.9
(—)
≥7
57.7
49.7
5.7
HR: hazard ratio, CI: confidence interval, NSCLC: Nonsmall cell lung cancer, BM at Diagnosis: brain metastases confirmed at primary diagnosis, KPS: Karnofsky performance status, SDNN: standard deviation of normal-to-normal interval, and RMSSD: root mean square standard deviation of normal-to-normal interval.