Sabiporide Reduces Ischemia-Induced Arrhythmias and Myocardial Infarction and Attenuates ERK Phosphorylation and iNOS Induction in Rats
Figure 2
(a) Scanning graphs of the infarct area in control rats and those that received sabiporide (1 mg/kg) prior to ischemia (Pre-Isch) or reperfusion (Pre-Rep). (b) Dose-dependent effects of sabiporide in myocardial infarct size. Open column: sabiporide (0.01, 0.03, 0.1, 0.3, 1.0, and 3.0 mg/kg) or saline was administered intravenously 10 minutes before occlusion. Black column: sabiporide (1.0 mg/kg) was administered intravenously at the start of reperfusion. All values are the , . versus the control group. versus sabiporide (1.0 mg/kg) prereperfusion group.
