Research Article
Sabiporide Reduces Ischemia-Induced Arrhythmias and Myocardial Infarction and Attenuates ERK Phosphorylation and iNOS Induction in Rats
Table 1
Hemodynamics in control and sabiporide-treated rats.
| | | Baseline | After 5 min drug treatment | Occlusion 30 min | Reperfusion | | | | | | 1 h | 2 h |
| | MBP (mmHg) | | | | | | | Control | | |
# |
# |
# | | Sabiporide (0.01 mg/kg Pre-Isch) | | |
# |
# |
# | | Sabiporide (0.1 mg/kg Pre-Isch) | | |
# |
# |
# | | Sabiporide (1 mg/kg Pre-Isch) | | |
# |
# |
# | | Sabiporide (3 mg/kg Pre-Isch) | | |
# |
# |
# | | Sabiporide (1 mg/kg Pre-Rep) | | |
# |
# |
# |
| | HR (bpm) | | | | | | | Control | | |
# |
# |
# | | Sabiporide (0.01 mg/kg Pre-Isch) | | |
# |
# |
# | | Sabiporide (0.1 mg/kg Pre-Isch) | | |
# |
# |
# | | Sabiporide (1 mg/kg Pre-Isch) | | |
# |
# |
# | | Sabiporide (3 mg/kg Pre-Isch) | | |
# |
# |
# | | Sabiporide (1 mg/kg Pre-Rep) | | |
# |
# |
# |
|
|
All values are the mean ± SEM, . # versus the baseline values.
|
