Systems Approaches to Modeling Chronic Mucosal Inflammation

Figure 4

Dysregulation of canonical NF-κB signaling in EMT. Left panel, heat map of NF-κB selective reporter genes. Data are Z-score-transformed and relative to unstimulated normal HSAECs and expressed as standard deviation (SD) units from the row mean. Scale for SD deviation is shown at the bottom. Right panel, quantitation of NFKBIA/IκBa and TNFAIP3/A20 gene expressions in HSAECs and EMT-HSAECs as indicated. Shown is fold change mRNA relative to unstimulated normal HSAECs. Each point is the mean of a duplicate biological experiment, measured with three technical replicates.