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BioMed Research International
Volume 2013, Article ID 520294, 9 pages
Review Article

Diagnosis Value of the Serum Amyloid A Test in Neonatal Sepsis: A Meta-Analysis

1Center for Systems Biology, Soochow University, Suzhou 215006, China
2Affiliated Children's Hospital of Soochow University, Suzhou 225121, China
3Suzhou Zhengxing Translational Biomedical Informatics Ltd., Taicang 215400, China

Received 29 April 2013; Accepted 4 July 2013

Academic Editor: Zhongming Zhao

Copyright © 2013 Haining Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Neonatal sepsis (NS), a common disorder for humans, is recognized as a leading global public health challenge. This meta-analysis was performed to assess the accuracy of the serum amyloid A (SAA) test for diagnosing NS. The studies that evaluated the SAA test as a diagnotic marker were searched in Pubmed, EMBASE, the Cochrane Library, and Google Network between January 1996 and June 2013. A total of nine studies including 823 neonates were included in our meta-analysis. Quality of each study was evaluated by the quality assessment of diagnostic accuracy studies tool (QUADAS). The SAA test showed moderate accuracy in the diagnosis of NS both at the first suspicion of sepsis and 8–96 h after the sepsis onset, both with , which is similar to the PCT and CRP tests for the diagnosis of NS in the same period. Heterogeneity between studies was also explained by cut-off point, SAA assay, and age of included neonates. On the basis of our meta-analysis, therefore, SAA could be promising and meaningful in the diagnosis of NS.