Diagnosis Value of the Serum Amyloid A Test in Neonatal Sepsis: A Meta-Analysis

Table 1

Characteristics of studies included in the meta-analysis of the diagnosis of neonatal sepsis using a SAA test.

Study and year	Study population	Patients (𝑛)	Region	Assay method	Time of SAA test: cutoff (mg/L)
Enguix et al. 2001 [31]	Cases: NICU neonates with sepsis	46	Spain	AMLN	Onset: 41.3
	Control: neonates without sepsis
Arnon et al. 2007 [21]	Cases: full-term neonates with sepsis; Control: neonates without sepsis	104	Israel	ALPIA	Onset: 8; 24 h after the onset: 10
Çetinkaya et al. 2009 [29]	Cases: NICU neonates with probable sepsis; Control: neonates without sepsis	163	Turkey	INMM	Onset: 68; 48 h after the onset: 68
Yildiz et al. 2008 [23]	Cases: NICU newborns with suspected sepsis; control: noninfected newborns	72	Turkey	ELISA	Onset: 5.5; 96 h after the onset: 5.7
Arnon et al. 2005 [22]	Cases: neonates with proven or clinical sepsis; Control: noninfected newborns	116	Israel	ELISA	Onset: 10; 8 h after the onset: 10
Arnon et al. 2002 [44]	Cases: preterm infants with sepsis or suspected sepsis; Control: healthy preterm infants	94	Israel	ELISA	Onset: 10
Edgar et al. 2010 [24]	Cases: term/preterm neonates with infection; Control: term/preterm neonates with infection	68	England	ELISA	Onset: 1
Mostafa et al. 2011 [45]	Cases: infants with sepsis or; suspected sepsis; Control: healthy neonates	100	Egypt	ELISA	Onset: >10
Mohsen et al. 2012 [30]	Cases: term/preterm neonate with sepsis; Control: healthy neonates	60	Egypt	ELISA	Onset: cases, 40.16 ± 35.17; control, 6.45 ± 2.42

AMLN: automatic laser nephelometry; ALPIA: automated latex photometric immunoassay; INMM: immunonephelometric method; ELISA: enzyme-linked immunoassay; HSAIA: highly sensitive automated immunoassays, and NICU: neonatal intensive care unit.