Kidney-Targeted Transplantation of Mesenchymal Stem Cells by Ultrasound-Targeted Microbubble Destruction Promotes Kidney Repair in Diabetic Nephropathy Rats
The endothelial cells of renal interstitial capillary were mildly injured under TEM and a part of interstitial capillary walls became thinner, discontinuous, and roughened in UTMD group ((a), arrow) and UTMD + MSCs group ((b), arrow), while the endothelial cells and interstitial capillary walls were kept intact in PBS group and MSCs group (c). (d) A trend graph for the change of blood glucose concentrations at 1, 2, 4, and 8 weeks after MSCs transplantation alone or together with UTMD. (e) 8 weeks after cell therapy, plasma insulin levels increased in MSCs group and UTMD + MSCs group, compared with PBS group and UTMD group, respectively. versus groups and versus groups. (f) MSCs transplantation with or without UTMD significantly decreased the increased UAER values of PBS group and UTMD group, and there was a statistical difference between MSCs group and UTMD + MSCs group. versus groups and versus groups.
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