Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in mdx Mice

Table 3

Schedule of mdx treatments for dystrophin restoration studies.

	Oral formulations	Frequency	No. of administrations	Total dose	Time of analysis
Group 1; Alginate-free; (𝑛=6)	ZM2 (2.5 mg)-AON (225 𝜇g); (𝑛=3)	2/week	32	240 mg/Kg	1 week after last administration
	ZM2 (2.5 mg); (𝑛=3)	2/week	32	—	1 week after last administration
Group II; Alginate-coated; (𝑛=6)	ZM2 (2.5 mg)-AON (200 𝜇g); (𝑛=3)	3/week	36	240 mg/Kg	1 week after last administration
	ZM2 (2.5 mg); (𝑛=3)	3/week	36	—	1 week after last administration
Group III; Untreated; (𝑛=3)	—	—	—	—	1 week after last administration