Sympathetic Innervation Induced in Engrafted Engineered Cardiomyocyte Sheets by Glial Cell Line Derived Neurotrophic Factor In Vivo
Figure 4
Sympathetic innervation in engrafted engineered cardiomyocyte sheets. (a) Representative images of immunofluorescent staining for -actinin (AA) and tyrosine hydroxylase (TH) in the control and GDNF grafts at 1, 2, and 4 weeks after cardiomyocyte sheets transplantation. Arrows indicate sympathetic nerves in the grafts. (b) Quantitative analysis of TH positive nerve area in the control and GDNF cardiomyocyte sheet grafts (, versus control, ). Scale bars indicate 200 μm. AA: -actinin; TH: tyrosine hydroxylase.