Research Article

Angiotensin II AT 1 Receptors Are Involved in Neuronal Activation Induced by Amphetamine in a Two-Injection Protocol

Figure 1

Average number of Fos-IR neurons in brain nuclei: dorsomedial region of CPu (a), Nacc core (b), and Nacc shell (c), in response to a challenge of saline ( = 4-5) or amphetamine ( = 5–8), 21 days after a pretreatment with cv or veh and a treatment with amph or sal (veh-sal, cv-sal, veh-amph, and cv-amph). Values are means ± SEM. significantly different from the other amphetamine-challenged groups (3-way ANOVA, post hoc Bonferroni).
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(a)  Caudado putamen
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(b) Nucleus accumbens core
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(c) Nucleus accumbens shell