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BioMed Research International
Volume 2013 (2013), Article ID 541018, 9 pages
Research Article

Brazilian Propolis: A Natural Product That Improved the Fungicidal Activity by Blood Phagocytes

Materials Science Postgraduate Program, Araguaia University Campus, Federal University of Mato Grosso, BR-070, Km 5, 78600-000 Barra do Garças, MT, Brazil

Received 3 September 2012; Revised 22 October 2012; Accepted 22 October 2012

Academic Editor: José Carlos Tavares Carvalho

Copyright © 2013 Muryllo Mendes Possamai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Natural product incorporation into microcarriers increases the bioavailability of these compounds, consequently improving their therapeutic properties. Natural products, particularly those from bees such as propolis, are widely used in popular medicine. Propolis is a powerful treatment for several diseases. In this context, the present study evaluated the effect of propolis Scaptotrigona sp. and its fractions, alone or adsorbed to polyethylene glycol (PEG) microspheres, on the activity of human phagocytes against Candida albicans. The results show that propolis exerts a stimulatory effect on these cells to assist in combating the fungus, especially as the crude extract is compared with the fractions. However, when incorporated into microspheres, these properties were significantly potentiated. These results suggest that propolis adsorbed onto PEG microspheres has immunostimulatory effects on phagocytes in human blood. Therefore, propolis may potentially be an additional natural product that can be used for a variety of therapies.