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BioMed Research International
Volume 2013, Article ID 543294, 12 pages
Research Article

Development of a Generic Microfluidic Device for Simultaneous Detection of Antibodies and Nucleic Acids in Oral Fluids

1Rheonix, Inc., Ithaca, NY 14850, USA
2Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA
3Department of Molecular Cell Biology, Leiden University Medical Center, Building 2, S-01-030, P.O. Box 9600, 2300 RC Leiden, The Netherlands
4Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA
5Department of Medicine, NYU School of Medicine, New York, NY, USA

Received 19 October 2012; Accepted 30 December 2012

Academic Editor: Joy Scaria

Copyright © 2013 Zongyuan Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Movie Legend: The operation of an open-structure prototype of the dual-path microfluidic device is shown. The chip was designed for simultaneous detection of antibodies and nucleic acid. The reagent chambers are pre-filled with colored solutions as surrogates for the various reagents and buffers in order to observe the fluid movement and mixing process. Automated processing is initiated after the manual addition of the sample to be analyzed. The antibody detection and the nucleic acid analysis paths proceed sequentially. Note: The timeline for the movie is compressed for demonstration purposes only.

  1. Supplementary Movie