- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 545983, 8 pages
Tyrosine Phosphorylation Modulates the Vascular Responses of Mesenteric Arteries from Human Colorectal Tumors
1Departamento de Cirugía General y Digestiva (Seccion B), Hospital Universitario “12 de Octubre”, Universidad Complutense, Avenida de Córdoba, s/n, 28041 Madrid, Spain
2Departamento de Fisiología, Universidad de Valencia, Avenida Blasco Ibáñez 15, 46010 Valencia, Spain
3INCLIVA, Instituto Investigación Sanitaria, Hospital Clínico Universitario, Avenida Blasco Ibáñez 15, 46010 Valencia, Spain
4Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, Spain
Received 22 April 2013; Revised 7 August 2013; Accepted 2 October 2013
Academic Editor: Gary E. Gallick
Copyright © 2013 Eduardo Ferrero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. Choura and A. Rebaï, “Receptor tyrosine kinases: from biology to pathology,” Journal of Receptors and Signal Transduction, vol. 31, no. 6, pp. 387–394, 2011.
- T. Hunter, “The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease,” Philosophical Transactions of the Royal Society B, vol. 353, no. 1368, pp. 583–605, 1998.
- S. Madhusudan and T. S. Ganesan, “Tyrosine kinase inhibitors in cancer therapy,” Clinical Biochemistry, vol. 37, no. 7, pp. 618–635, 2004.
- G. Elberg, J. Li, A. Leibovitch, and Y. Shechter, “Non-receptor cytosolic protein tyrosine kinases from various rat tissues,” Biochimica et Biophysica Acta, vol. 1269, no. 3, pp. 299–306, 1995.
- J. Yu, K. Mizumoto, T. Kakutani, A. Hasegawa, K. Ogawa, and Y. Hatano, “Comparison of the effects of isoflurane and sevoflurane on protein tyrosine phosphorylation-mediated vascular contraction,” Acta Anaesthesiologica Scandinavica, vol. 49, no. 6, pp. 852–858, 2005.
- N. Villalba, A. Kun, E. Stankevicius, and U. Simonsen, “Role for tyrosine kinases in contraction of rat penile small arteries,” Journal of Sexual Medicine, vol. 7, no. 6, pp. 2086–2095, 2010.
- Ö. Uzun and A. T. Demiryürek, “Involvement of tyrosine kinase pathway in acute hypoxic vasoconstriction in sheep isolated pulmonary vein,” Vascular Pharmacology, vol. 40, no. 3, pp. 175–181, 2003.
- T. Kitazono, S. Ibayashi, T. Nagao, K. Fujii, T. Kagiyama, and M. Fujishima, “Role of tyrosine kinase in dilator responses of rat basilar artery in vivo,” Hypertension, vol. 31, no. 3, pp. 861–865, 1998.
- P. Carmeliet, “VEGF as a key mediator of angiogenesis in cancer,” Oncology, vol. 69, supplement 3, pp. 4–10, 2005.
- A.-K. Olsson, A. Dimberg, J. Kreuger, and L. Claesson-Welsh, “VEGF receptor signalling—in control of vascular function,” Nature Reviews Molecular Cell Biology, vol. 7, no. 5, pp. 359–371, 2006.
- E. Stuttfeld and K. Ballmer-Hofer, “Structure and function of VEGF receptors,” IUBMB Life, vol. 61, no. 9, pp. 915–922, 2009.
- N. Ferrara, “Vascular endothelial growth factor: basic science and clinical progress,” Endocrine Reviews, vol. 25, no. 4, pp. 581–611, 2004.
- V. Dymicka-Piekarska, K. Guzinska-Ustymowicz, A. Kuklinski, and H. Kemona, “Prognostic significance of adhesion molecules (sICAM-1, sVCAM-1) and VEGF in colorectal cancer patients,” Thrombosis Research, vol. 129, no. 4, pp. e47–e50, 2012.
- J. E. Peterson, D. Zurakowski, J. E. Italiano Jr. et al., “VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients,” Angiogenesis, vol. 15, no. 2, pp. 265–273, 2012.
- N. R. Smith, D. Baker, N. H. James et al., “Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers,” Clinical Cancer Research, vol. 16, no. 14, pp. 3548–3561, 2010.
- H. Amaya, N. Tanigawa, C. Lu et al., “Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer,” Cancer Letters, vol. 119, no. 2, pp. 227–235, 1997.
- A. K. Srivastava, “Protein tyrosine phosphorylation in cardiovascular system,” Molecular and Cellular Biochemistry, vol. 149-150, pp. 87–94, 1995.
- D. F. Sellitti, E. Puggina, C. Lagranha et al., “TGF-β-like transcriptional effects of thyroglobulin (Tg) in mouse mesangial cells,” Endocrine Journal, vol. 54, no. 3, pp. 449–458, 2007.
- G. L. Peterson, “A simplification of the protein assay method of Lowry et al. Which is more generally applicable,” Analytical Biochemistry, vol. 83, no. 2, pp. 346–356, 1977.
- L. B. Jakeman, M. Armanini, H. S. Phillips, and N. Ferrara, “Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis,” Endocrinology, vol. 133, no. 2, pp. 848–859, 1993.
- S. Alcón, P. J. Camello, L. J. García, and M. J. Pozo, “Activation of tyrosine kinase pathway by vanadate in gallbladder smooth muscle,” Biochemical Pharmacology, vol. 59, no. 9, pp. 1077–1089, 2000.
- L. Grasa, M. P. Arruebo, M. A. Plaza, and M. D. Murillo, “The role of tyrosine kinase in prostaglandin E2 and vanadate-evoked contractions in rabbit duodenum in vitro,” Journal of Physiology and Pharmacology, vol. 57, no. 2, pp. 279–289, 2006.
- H. E. Kafl and H. A. Elkashef, “Effect of sodium orthovanadate on the urinary bladder rings isolated from normal and hyperglycemic rats,” Pakistan Journal of Pharmaceutical Sciences, vol. 19, no. 3, pp. 195–201, 2006.
- L. Zhao, Z. Wang, Y.-C. Ruan, and W.-L. Zhou, “Cellular mechanism underlying the facilitation of contractile response of vas deferens smooth muscle by sodium orthovanadate,” Molecular and Cellular Biochemistry, vol. 366, no. 1-2, pp. 149–157, 2012.
- S. Wijetunge, C. Aalkjaer, M. Schachter, and A. D. Hughes, “Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells,” Biochemical and Biophysical Research Communications, vol. 189, no. 3, pp. 1620–1623, 1992.
- H. Masui and I. Wakabayashi, “Tyrosine phosphorylation increases Ca2+ sensitivity of vascular smooth muscle contraction,” Life Sciences, vol. 68, no. 4, pp. 363–372, 2000.
- J. Di Salvo, G. Pfitzer, and L. A. Semenchuk, “Protein tyrosine phosphorylation, cellular Ca2+, and Ca2+ sensitivity for contraction of smooth muscle,” Canadian Journal of Physiology and Pharmacology, vol. 72, no. 11, pp. 1434–1439, 1994.
- B. J. Adegunloye, X. Su, E. V. Camper, and R. S. Moreland, “Sensitivity of rabbit aorta and mesenteric artery to norepinephrine: role of tyrosine kinases,” European Journal of Pharmacology, vol. 476, no. 3, pp. 201–209, 2003.
- T. Hisayama, K. Kida, K. Imada, and H. Moritoki, “Tyrosine kinase may participate in Ca2+ entry for endothelial nitric oxide production,” Japanese Journal of Pharmacology, vol. 67, no. 2, pp. 181–183, 1995.
- J. M. Muller, M. J. Davis, and W. M. Chilian, “Coronary arteriolar flow-induced vasodilation signals through tyrosine kinase,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 270, no. 6, part 2, pp. H1878–H1884, 1996.
- R. Nakaike, H. Shimokawa, M. K. Owada et al., “Vanadate causes synthesis of endothelium-derived NO via pertussis toxin- sensitive G protein in pigs,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 271, no. 1, part 2, pp. H296–H302, 1996.
- S. Sharma, M. Singh, and P. L. Sharma, “Mechanism of attenuation of diabetes mellitus and hypercholesterolemia induced vascular endothelial dysfunction by protein tyrosine phosphatase inhibition,” Vascular Pharmacology, vol. 54, no. 3–6, pp. 80–87, 2011.
- M. H. M. Yousif, I. F. Benter, and S. Akhtar, “The role of tyrosine kinase-mediated pathways in diabetes-induced alterations in responsiveness of rat carotid artery,” Autonomic and Autacoid Pharmacology, vol. 25, no. 2, pp. 69–78, 2005.
- D. I. Shah and M. Singh, “Inhibition of protein tyrosin phosphatase improves vascular endothelial dysfunction,” Vascular Pharmacology, vol. 44, no. 3, pp. 177–182, 2006.
- P. B. Furspan, S. Chatterjee, M. D. Mayes, and R. R. Freedman, “Cooling-induced contraction and protein tyrosine kinase activity of isolated arterioles in secondary Raynaud's phenomenon,” Rheumatology, vol. 44, no. 4, pp. 488–494, 2005.
- C. Fetscher, H. Chen, R. F. Schäfers, G. Wambach, G. Heusch, and M. C. Michel, “Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 363, no. 1, pp. 57–65, 2001.
- C. Liu, T. Tazzeo, H. Lippton, and L. J. Janssen, “Role of tyrosine phosphorylation in U46619-induced vasoconstriction of pulmonary vasculature and its modulation by genistein, daidzein, and equol,” Journal of Cardiovascular Pharmacology, vol. 50, no. 4, pp. 441–448, 2007.
- K. Tasaki, M. Hori, H. Ozaki, H. Karaki, and I. Wakabayashi, “Difference in signal transduction mechanisms involved in 5-hydroxytryptamine- and U46619-induced vasoconstrictions,” Journal of Smooth Muscle Research, vol. 39, no. 5, pp. 107–117, 2003.
- M. Watanabe, M. Doi, K. Sasaki, and A. Ogawa, “Modulatory role of protein tyrosine kinase activation in the receptor- induced contractions of the bovine cerebral artery,” Neurologia Medico-Chirurgica, vol. 38, no. 2, pp. 75–82, 1998.
- C. Métais, L. I. Jianyi, L. I. Jian, M. Simons, and F. W. Sellke, “Effects of coronary artery disease on expression and microvascular response to VEGF,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 275, no. 4, pp. H1411–H1418, 1998.
- F. W. Sellke, S. Y. Wang, A. Stamler et al., “Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 271, no. 2, pp. H713–H720, 1996.
- A. J. LeBlanc, R. D. Shipley, L. S. Kang, and J. M. Muller-Delp, “Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 295, no. 6, pp. H2280–H2288, 2008.
- P. Brownbill, G. C. McKeeman, J. C. Brockelsby, I. P. Crocker, and C. P. Sibley, “Vasoactive and permeability effects of vascular endothelial growth factor-165 in the term in vitro dually perfused human placental lobule,” Endocrinology, vol. 148, no. 10, pp. 4734–4744, 2007.
- E. R. Jacobs, D. Zhu, S. Gruenloh, B. Lopez, and M. Medhora, “VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 291, no. 3, pp. L369–L377, 2006.
- M. H. Liu, H. Jin, H. S. Floten, Z. Ren, A. P. Yim, and G. W. He, “Vascular endothelial growth factor-mediated, endothelium-dependent relaxation in human internal mammary artery,” Annals of Thoracic Surgery, vol. 73, no. 3, p. 819, 2002.
- W. Wei, Z.-W. Chen, Q. Yang et al., “Vasorelaxation induced by vascular endothelial growth factor in the human internal mammary artery and radial artery,” Vascular Pharmacology, vol. 46, no. 4, pp. 253–259, 2007.
- A. N. Carr, M. G. Davis, E. Eby-Wilkens et al., “Tyrosine phosphatase inhibition augments collateral blood flow in a rat model of peripheral vascular disease,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 287, no. 1, pp. H268–H276, 2004.
- J. Oshikawa, N. Urao, H. W. Kim et al., “Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice,” PLoS ONE, vol. 5, no. 4, Article ID e10189, 2010.
- M. Sugano, K. Tsuchida, and N. Makino, “A protein tyrosine phosphatase inhibitor accelerates angiogenesis in a rat model of hindlimb ischemia,” Journal of Cardiovascular Pharmacology, vol. 44, no. 4, pp. 460–465, 2004.
- W. Wei, H. Jin, Z.-W. Chen, T. F. Zioncheck, A. P. C. Yim, and G.-W. He, “Vascular endothelial growth factor-induced nitric oxide-and PGI 2-dependent relaxation in human internal mammary arteries: a comparative study with KDR and Flt-1 selective mutants,” Journal of Cardiovascular Pharmacology, vol. 44, no. 5, pp. 615–621, 2004.
- B. Li, A. K. Ogasawara, R. Yang et al., “KDR (VEGF receptor 2) is the major mediator for the hypotensive effect of VEGF,” Hypertension, vol. 39, no. 6, pp. 1095–1100, 2002.
- H. He, V. J. Venema, X. Gu, R. C. Venema, M. B. Marrero, and R. B. Caldwell, “Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through Flk-1/KDR activation of c-Src,” The Journal of Biological Chemistry, vol. 274, no. 35, pp. 25130–25135, 1999.
- H. Sartelet, M. Decaussin, G. Devouassoux et al., “Expression of vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1 [Flt-1] and VEGF-R2 [KDR/Flk-1]) in tumorlets and in neuroendocrine cell hyperplasia of the lung,” Human Pathology, vol. 35, no. 10, pp. 1210–1217, 2004.
- M. Schmidt, H.-U. Voelker, M. Kapp, J. Dietl, and U. Kammerer, “Expression of VEGFR-1 (Flt-1) in breast cancer is associated with VEGF expression and with node-negative tumour stage,” Anticancer Research, vol. 28, no. 3, pp. 1719–1724, 2008.
- J. C. Reubi, A. Fleischmann, B. Waser, and R. Rehmann, “Concomitant vascular GRP-receptor and VEGF-receptor expression in human tumors: molecular basis for dual targeting of tumoral vasculature,” Peptides, vol. 32, no. 7, pp. 1457–1462, 2011.
- H. Takahashi and M. Shibuya, “The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions,” Clinical Science, vol. 109, no. 3, pp. 227–241, 2005.
- H. Huang, J. Held-Feindt, R. Buhl, H. M. Mehdorn, and R. Mentlein, “Expression of VEGF and its receptors in different brain tumors,” Neurological Research, vol. 27, no. 4, pp. 371–377, 2005.
- B. J. Ljungberg, J. Jacobsen, S. H. Rudolfsson, G. Lindh, K. Grankvist, and T. Rasmuson, “Different vascular endothelial growth factor (VEGF), VEGF-receptor 1 and -2 mRNA expression profiles between clear cell and papillary renal cell carcinoma,” BJU International, vol. 98, no. 3, pp. 661–667, 2006.
- J. M. Mehnert, M. M. McCarthy, L. Jilaveanu et al., “Quantitative expression of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 in melanoma tissue microarrays,” Human Pathology, vol. 41, no. 3, pp. 375–384, 2010.
- J. Pallares, F. Rojo, J. Iriarte, J. Morote, L. I. Armadans, and I. de Torres, “Study of microvessel density and the expression of the angiogenic factors VEGF, bFGF and the receptors Flt-1 and FLK-1 in benign, premalignant and malignant prostate tissues,” Histology and Histopathology, vol. 21, no. 8, pp. 857–865, 2006.
- Y. Harada, Y. Ogata, and K. Shirouzu, “Expression of vascular endothelial growth factor and its receptor KDR (kinase domain-containing receptor)/Flk-1 (fetal liver kinase-1) as prognostic factors in human colorectal cancer,” International Journal of Clinical Oncology, vol. 6, no. 5, pp. 221–228, 2001.
- N. T. Okita, Y. Yamada, D. Takahari et al., “Vascular endothelial growth factor receptor expression as a prognostic marker for survival in colorectal cancer,” Japanese Journal of Clinical Oncology, vol. 39, no. 9, pp. 595–600, 2009.
- Y. Yin, L.-Y. Cao, W.-Q. Wu, H. Li, Y. Jiang, and H.-F. Zhang, “Blocking effects of siRNA on VEGF expression in human colorectal cancer cells,” World Journal of Gastroenterology, vol. 16, no. 9, pp. 1086–1092, 2010.
- D. Wang, D. B. Donner, and R. S. Warren, “Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF,” The Journal of Biological Chemistry, vol. 275, no. 21, pp. 15905–15911, 2000.
- E. Ferrero, M. Labalde, N. Fernandez et al., “Response to endothelin-1 in arteries from human colorectal tumours: role of endothelin receptors,” Experimental Biology and Medicine, vol. 233, no. 12, pp. 1602–1607, 2008.
- G. Neufeld, T. Cohen, S. Gengrinovitch, and Z. Poltorak, “Vascular endothelial growth factor (VEGF) and its receptors,” FASEB Journal, vol. 13, no. 1, pp. 9–22, 1999.