Prevalence and Genetic Variability in Capsid L1 Gene of Rare Human Papillomaviruses (HPV) Found in Cervical Lesions of Women from North-East Brazil

Table 7

Nucleotide sequence variation in the L1 gene of HPV-62. The vertical numbers indicate the position of the nucleotide variations. HG: Histopathological grade. (*) Substitutions not previously reported.

HPV-62 L1 gene variability	6; 7; 6; 3	6; 8; 2; 7	6; 8; 3; 8	6; 8; 4; 7	6; 9; 2; 1	6; 9; 2; 5	7; 0; 5; 5	7; 1; 1; 4	7; 1; 5; 9	HG
Prototype (AY395706)	A	G	A	T	A	A	A	A	C	CIN III
165 PE	C	A	C*	C	G*	G	G	C	T
Protein	E329D	A351T	E354D		Q382R		T427A
Hydropathic index	Hydrophilic/Hydrophobic	Hydrophobic/Hydrophilic	Hydrophobic/Hydrophobic		Hydrophilic/Hydrophilic		Hydrophilic/Hydrophobic
Biological functions altered	MHC Class-I/MHC Class-II/ B-cell epitopes	MHC Class-I/MHC Class-II	MHC Class-II/B-cell epitopes		MHC Class-I/MHC Class-II/B-cell epitopes		MHC Class-I/MHC Class-II