Leptin Modulates Norepinephrine-Mediated Melatonin Synthesis in Cultured Rat Pineal Gland

<table>Leptin effect on <i>Tpoh, Aanat,</i> and <i>Hiomt</i> mRNA expression in cultured rat pineal gland. The glands were challenged with leptin (Lep 1 nM) associated with norepinephrine (NE 1 <i>μ</i>M). (a) Tryptophan hydroxylase (<i>Tpoh</i>) mRNA expression. (b) Arylalkylamine-N-acetyl transferase (<i>Aanat</i>) mRNA expression. (c) Hydroxyindole-O-methyltransferase (<i>Hiomt</i>) mRNA expression. One-way ANOVA, followed by Bonferroni’s post hoc test. <svg height="13.95" id="M20" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus control. Data are reported as the number of transcripts per number of ribosomal protein L37a (<i>Rpl37a</i>) molecules. <svg height="11.225" id="M21" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> glands/group and each experiment was repeated 3 times.</table>

BioMed Research International

fig3

Figure 3

Figure 3: Leptin Modulates Norepinephrine-Mediated Melatonin Synthesis in Cultured Rat Pineal Gland 