Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [¹²⁴I]-Morpholino-IPQA

Table 1

Pharmacokinetics of morpholino-[¹³¹I]IPQA accumulation and washout in different tumor cells in vitro.

Tumor cells	L858R	E746-A750 del	EGFR	Vector
Plateau level at 60 minutes^1	3.12±0.304	1.57±0.17	1.47±0.001	1.47±0.001
Washout at 60 minutes^2	1.78±0.147^∗	1.10±0.16	1.17±0.001	1.17±0.001
Washout at 21 minutes	1.09±0.124^∗	1.16±0.20	0.55±0.000^∗	0.55±0.000^∗

¹Volume of distribution at equilibrium expressed as cell-to-medium accumulation ratio (average ± standard error). ²Coefficient 𝐵 (slope) of the exponential washout = A × exp^(−BX).