BioMed Research International / 2013 / Article / Fig 3

Review Article

Oligomannose-Coated Liposome as a Novel Adjuvant for the Induction of Cellular Immune Responses to Control Disease Status

Figure 3

Preferential secretion of IL-12 from phagocytic cells. (a) The peritoneal phagocytic cells were collected 1 h after the administration of liposomes into peritoneal cavity and cultured for 18 h. IL-12 and IL-6 secreted into culture media were determined. Note that specific IL-12 production and suppression of IL-6 production were observed in the cells that took up OMLs (Man3 or Man5), while carbohydrate uncoated liposomes (Bare lipo) and liposomes coated with lacto-N-tetraose, which has terminal galactose residue (LNT), were not affected in secretion of IL-12 and IL-6. (b) Intracellular staining of IL-12 of peritoneal phagocytic cells that ingested OMLs. IL-12 was produced by CD11b+CD11c+ (R2 in Figure 2) cells.
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