Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms
Figure 4
3,5-diiodo-L-thyronine T2 reduces immobility time in the tail suspension test. On Day 1 and 2 of the tail suspension test, mice treated with 250 mcg/kg of T2 30 min before (a) or 2 h after (b) the first session of testing showed no differences in the latency of immobility and in the duration of this behaviour. (c) Mice treated with 750 mcg/kg of T2 30 min prior to the first test session had a trend towards longer latency of immobility on Day 1 and significant increase in this parameter on Day 2; the duration of immobility was significantly reduced. (d) Animals that received the dose of 750 mcg/kg of T2 2 h after the first session of testing had significant increase in the latency of immobility on Day 2, and the duration of immobility had a tendency to a decrease. On Day 1, prior to treatment, mice from two groups had similar behavioural scores. (e) Mice dosed with 1500 mcg/kg of T2 30 min prior to the first test session had a trend towards longer latency of immobility on Days 1 and 2; the duration of immobility was significantly reduced. versus control.
