Sensitivity of Rabbit Ventricular Action Potential and Ca2+ Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients
Figure 3
Verification of ion conductance sensitivity predictions. Steady-state AP and transients (recorded 9-10 s) in each of the three non-SR compartments in response to 1 Hz stimulus. The predicted changes in and peaks (see Insets also) are consistent with the generated by Nimrod/E and PLS outputs with respect to 10% increases in transporters’ conductance. Control conductance values (black solid line) and 10% increases in (black dashed line), (black dash-dot line), (gray dash-dot line), (gray solid line), (gray dotted line), and (black dotted line).