Sensitivity of Rabbit Ventricular Action Potential and Ca2+ Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients
Table 1
Maximal conductance varied in the model.
Definition
Symbol
Baseline value
1
Maximal Na+ conductance
16 mS/F
2
Background Na+ conductance
()
0.297 10−3 mS/µF
3
Maximal rapid delayed rectifier K+ conductance
()
0.07 mS/µF
4
Maximal slow delayed rectifier K+ conductance
0.013 mS/µF
5
Maximal fast transient outward K+ conductance
0.06 mS/µF
6
Maximal slow transient outward K+ conductance
()
0.02 mS/µF
7
Maximal inward rectifier K+ conductance
0.9 mS/µF
8
Maximal Ca-activated Cl− conductance
0.109625 mS/µF
9
Background Cl− conductance
0.009 mS/µF
10
Maximal permeability of L-type Ca2+ channel for Ca2+
()
5.4 10−4 cm/s
11
Maximal permeability of L-type Ca2+ channel for Na+
()
1.5 10−8 cm/s
12
Maximal permeability of L-type Ca2+ channel for K+
()
2.7 10−7 cm/s
13
Background Ca2+ conductance
()
0.0002513 ms/µF
14
Maximal Na+-Ca2+ exchange current
()
9 A/F
15
Maximal sarcolemmal Ca2+ pump current
()
0.0673 A/F
16
Maximal Na+-K+ pump current
()
1.91 A/F
17
SR Ca2+ release scaling factor
()
25 ms−1
18
Maximal rate of SR Ca2+ uptake (SERCA)
()
5.3 10−3 mM/ms
19
Passive SR Ca2+ leak scaling factor
()
5.348 10−6 ms−1
Note: notations in brackets, for example, (…), show corresponding notations of some parameters used in Shannon et al. article [1]. The baseline conductance values used in this study are the same as in [1].
