Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells
Figure 4
Antioxidative effects of aqueous extract of Cordyceps sinensis in A549 cells exposed to different oxygen percentages (0.1, 0.5%, 1%, or 5% O2; (a)–(d)) for 48 h. Cells exposed to hypoxia showed elevated levels of reactive oxygen species (dark gray bars) compared to unexposed cells (black bars) which was dependent on oxygen percentage. Cordyceps sinensis decreased reactive oxygen species following hypoxia exposure and the efficacy of extract was dose dependent (light gray bars). *.
