BioMed Research International / 2013 / Article / Tab 3

Review Article

Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Table 3

Secondary compounds with anti-inflammatory effects.

Active compoundClassModels of ALIDosesRelevant findingsReference

Matrine Alkaloid ALI in mice induced by LPS 25, 50, and 100 mg/kg Lung edema, MPO, TNF-α, IL-6, and NF- B[154]
NicotineAlkaloidALI in mice induced by LPS0.2 and 0.4 mg/kg Lung edema, leukocytes, MPO, total protein, IL-1, IL-6, and TNF-α[155, 156]
ALI in mice induced by LPS50, 250, and 500 mg/kg Lung edema, MPO, TNF-α, and IL-1β[157]
TheophyllineAlkaloidALI in guinea pigs induced by LPS3 and 30 mg/kg Leukocytes, and IL-10[103]
AndrographolideDiterpenoidALI in mice induced by LPS1 and 10 mg/kg Lung edema, leukocytes, MPO, IL-6, TNF-α, IL-1β, and NF- B[59]
AstragalinFlavonoidALI in mice induced by LPS50 and 75 mg/kg Leukocytes, neutrophils, IL-1β, TNF-α, and IL-6[158]
Caffeic acid phenethyl esterFlavonoidALI in rats induced by phosgene50 mg/kg NF- B, and p38 MAPK[159]
CardamoninFlavonoidALI in mice induced by LPS 10, 30, and 100 mg/kg Lung edema, TNF-α, IL-6, and p38 MAPK[160]
Epigallocatechin-3-gallateFlavonoidALI in rats induced by LPS10, 50, and 100 mg/kg Lung edema, neutrophils, TNF-α, MIP-2, and ERK [63]
FlavonoidALI in rats induced by oleic acid Lung edema, TNF-α, and p38 MAPK[87]
KaempferolFlavonoidALI in mice induced by LPS 100 mg/kg Leukocytes, neutrophils, MPO, TNF-α, IL-1β, IL-6, ERK, and NF- B[161]
LuteolinFlavonoidALI in mice induced by LPS 35 and 70  mol/kg neutrophils, MPO, MAPK, and NF- B [85]
ALI in mice induced by LPS70, 35, and 18  mol /kg neutrophils, IL-6, TNF-α, and NF- B[84]
NaringinFlavonoidALI in mice induced by LPS15, 30, and 60 mg/kg Leukocytes, neutrophils, MPO, TNF-α, and NF- B[162]
ALI in mice induced by Paraquat60 and 120 mg/kg Leukocytes, TNF-α, TGF-β1, and MMP-9[163]
Oroxylin AFlavonoidALI in rats induced by LPS 15 mg/kg Neutrophils, TNF-α, and NF- B[164]
QuercetinFlavonoidALI in rats induced by LPS1, 5, and 10 mg/kg MPO, TNF-α, and IL-8[165]
Geniposide IridoideALI in mice induced by LPS20, 40, and 80 mg/kg Leukocytes, MPO, IL-6, TNF-α, and IL-10[166]
Genistein*Isoflavonoid ALI in rats induced by LPS50 mg/kg Lung edema, PMN, MPO, and ICAM-1[167]
ALI in rats induced by LPS50 mg/kg MMP-9, NO, and NF- B[168]
Curcumin*PolyphenolALI in rats induced by phosgene50 and 200 mg/kg Leukocytes, Lung edema, total protein, MPO, TNF-α, and IL-8[96]
ALI in rats induced by sepsis200 mg/kg TGF-β1[94]
ALI in rates induced by LPS Lung edema, neutrophils, and NF- B[169]
ALI in rats induced by intestinal ischemia/reperfusion100 mg/kg Leukocytes[96]
ALI in rats induced by oleic acid5, 10, and 20 mg/kg Lung edema, TNF-α, and IL-10[99]
Ellagic acidPolyphenolALI in mice induced by acid10 mg/kg Lung edema, neutrophils, IL-6, COX-2, NF- B, and AP-1[60]
EscinSaponin ALI in mice induced by LPS0.9, 1.8, and 3.6 mg/kg MPO, TNF- , and IL-1 [170]
GlycyrrhizinTriterpeneALI in mice induced by LPS10, 25, and 50 mg/kg Lung edema, neutrophils, MPO, COX-2, and iNOS[171]
ALI in mice induced by LPS30, 10, and 3 mg/kg TNF-α and IL-10[172]
Hydroxysafflor yellow AALI in mice induced by LPS 6, 15, and 37.5 mg/kg Leukocytes, lung edema, TNF-α, IL-1β, IL-6, p38 MAPK, and NF- B[173]
ALI in rats induced by oleic
acid and LPS
20, 40, and 60 mg/kg Leukocytes, lung edema TNF-α, IL-6, IL-1β, and ICAM-1[174]

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