CTLA-4 Expression and Polymorphisms in Lung Tissue of Patients with Diagnosed Non-Small-Cell Lung Cancer

Table 4

CTLA-4 +49 A/G and −318 C/T genotype and allele distribution in blood samples of NSCLC patients in comparison with the control group.

CTLA-4 genotypes and alleles	NSCLC patients 𝑛=71		Healthy controls 𝑛=104		OR (CI 95%)	𝑃 value
	Number	Frequency	Number	Frequency
+49 AA	56	0.80	49	0.47	4.19 (2.11–8.33)	0.58
+49 AG	13	0.18	33	0.32	0.48 (0.23–1.02)	0.23
+49 GG	2	0.02	22	0.21	0.11 (0.02–0.48)	0.03
	𝜒^2=1.23𝑃=0.73		𝜒^2=3.26𝑃=0.37
+49 A allele	63	0.88	131	0.63	4.32 (2.42–7.72)	0.47
+49 G allele	79	0.12	77	0.37	0.23 (0.13–0.41)	0.47
−318 CC	59	0.83	36	0.34	9.29 (0.42–9.48)	0.76
−318 CT	10	0.14	37	0.36	0.30 (0.14–2.65)	0.57
−318 TT	2	0.03	31	0.30	0.10 (0.02–0.30)	0.02
	𝜒^2=2.67𝑃=0.25		𝜒^2=4.65𝑃=0.35
−318 C allele	128	0.90	109	0.60	8.30 (0.5–15.36)	0.23
−318 T allele	14	0.10	99	0.40	0.12 (0.65–2.22)	0.23