Expression Systems and Species Used for Transgenic Animal Bioreactors

Table 1

Comparison of the different systems used to produce recombinant pharmaceutical proteins.

	Bacteria	Mammalian cells	Transgenic animals
Production level	++	+	++++
Investment cost	+++++	+	+++
Production cost	+++++	++	++++
Scaling-up ability	+++++	+	++++
Collection	+++++	+++++	++++
Purification	+++	++++	+++
Posttranslational modifications	+	++++	++++
Glycosylation	+	++++	++++
Stability of product	+++++	+++	++++
Contaminant pathogens	+++++	++++	++++
Products on the market	++++	+++++	+++

Table adapted from [1].