In Vitro and In Vivo Survival and Colonic Adhesion of Pediococcus acidilactici MTCC5101 in Human Gut

Table 5

Studies of oral dosage levels of probiotics in healthy volunteers and patients.

Organism(s)	Subjects	Dose levels (CFU/mL/day)	Response/outcomes	Reference
Lactobacillus paracasei subsp. paracasei (CRL-431); L. acidophilus	Children and adults with diarrhea	10^7-10^8	Three 15 day trial periods; reduction in incidence of intestinal disorders	[25]
Lactobacillus GG	Healthy volunteers	10^8–10^10	1-week trial; effective gut colonization	[26]
Bifidobacterium lactis BB-12; Lactobacillus GG	Children with atopic eczema	10^8-10^9	2-month trial; controlled allergic reactions	[27]
B. longum SBT2928	Healthy volunteers	10^11	40-day trial; survival in the gut	[28]
Lactobacillus GG	Children with acute infectious diarrhea	10^9	Prophylactic; reduction in duration of diarrhea	[29]
L. casei subsp. rhamnosus Lcr35	Healthy volunteers	10^8–10^12	1-week study; successful colonization of gut	[30]
L. reuteri ATCC 55730	Healthy volunteers	10^8	28-day trial; gut colonization; immune modulation	[31]
B. animalis subsp. lactis BB-12; Streptococcus thermophilus	Children with rotavirus diarrhea	10^8	Reduction in incidence of acute diarrhea and rotavirus shedding	[32]
B. lactis strain BB12	Healthy breastfed infants	10^6	Prophylactic against acute diarrhea	[33]
B. animalis subsp. lactis BB-12; L. reuteri ATCC 55730	Children with acute diarrhea	10^7	12-week trial; fewer and shorter episodes of diarrhea	[34]
L. delbrueckii subsp. bulgaricus; S. thermophilus	Healthy volunteers	10^7–10^9; (L. delbrueckii); 10^8–10^10; (S. thermophilus)	12-day trial; effective gut colonization	[35]
B. animalis subsp. lactis BB-12; L. paracasei subsp. paracasei CRL-431	Healthy volunteers	10^8–10^11	7-week study; fecal recovery increases with increase in dose	[36]
L. reuteri DSM 17938; L. rhamnosus GG	Healthy volunteers	10^9	3-week trial; increase in fecal recovery of viable lactobacilli	[37]
Pediococcus acidilactici MTCC 5101	Healthy human volunteers	10^8–10^10	4-week trial; colonization and fecal recovery increases with time	Present study