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BioMed Research International
Volume 2013 (2013), Article ID 585134, 7 pages
Research Article

Association of Apolipoprotein A5 Gene 1131T C Polymorphism with the Risk of Metabolic Syndrome in Korean Subjects

Division of Constitutional Medicine Research, and Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 483 Expo-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea

Received 20 August 2012; Accepted 26 December 2012

Academic Editor: M. Ilyas Kamboh

Copyright © 2013 Kwang Hoon Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We assessed the associations between the APOA5 1131T C polymorphism and lipid parameters and other risk factors of the metabolic syndrome in Korean subjects. A total of 2,901 participants from 20 oriental medical hospitals in Korea were enrolled between 2006 and 2011. According to the modified National Cholesterol Education Program Adult Treatment Panel III definitions, subjects were classified into the metabolic syndrome group and control group. The APOA5 1131T C genotype was significantly associated with serum high-density lipoprotein cholesterol levels (effect = − 1.700 mg/dL, -E07) in the total study population after adjustment for differences in age and gender. The association of the APOA5 1131T C genotype with serum log-transformed triglyceride was also significant in an additive genetic model (effect = 0.056 mg/dL, E-19). After adjustment for age and gender, we determined that the odds ratio for the occurrence of the metabolic syndrome was 1.322 for C-allele carriers in the additive model (95% CI = [1.165 − 1.501], E-05). In the current study, we demonstrated that the APOA5 1131T C polymorphism is associated with the metabolic syndrome because of its remarkable effect on serum triglyceride levels in Korean subjects.