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BioMed Research International
Volume 2013, Article ID 587460, 8 pages
Review Article

The Variety of Vertebrate Mechanisms of Sex Determination

Department of Genetics and Biotechnology, Saint-Petersburg State University, Saint-Petersburg 199034, Russia

Received 27 February 2013; Revised 26 September 2013; Accepted 28 October 2013

Academic Editor: Vassily Lyubetsky

Copyright © 2013 Antonina V. Trukhina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The review deals with features of sex determination in vertebrates. The mechanisms of sex determination are compared between fishes, amphibians, reptilians, birds, and mammals. We focus on structural and functional differences in the role of sex-determining genes in different vertebrates. Special attention is paid to the role of estrogens in sex determination in nonmammalian vertebrates.