Review Article
The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability
Table 5
Overview of the data addressed in this review.
| Micronutrient | Evidence of genomic instability induction | Concentration in common cell-culture media versus physiological concentration | Optimal concentration proposed for cell culture | Deficiency | Excess |
| Vitamin A | + | + | Lower | Studied | Vitamin B7 | + | + | Higher | Requires more studies | Vitamin B9 | + | + | Higher | Studied | Vitamin B12 | + | NA | Higher | Studied | Vitamin C | + | + | Unknown | Studied | Vitamin E | − | + | Unknown | Studied | Copper | + | + | Lower | Studied | Iron | + | + | Lower | Studied | Magnesium | NA | + | Similar | Studied | Selenium | + | − | Lower | Studied | Zinc | + | + | Lower | Studied |
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NA: Not available. (−) Negative: the available data indicate no effect. (+) Positive: the available data indicate an effect.
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