Research Article

A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder

Figure 1

Association between rs2205960 and rs10489265 with TNFSF4 mRNA expression in cell lines. (a) The expression of TNFSF4 in transformed B-cell lines from healthy HapMap samples is shown. For space limitation, only data from US individuals with European ancestry (CEU) and Han Chinese individuals from Beijing (CHB) were shown. CEU: 109 Caucasians living in Utah, USA, of northern and western European ancestries; CHB: 80 Han Chinese from Beijing, China. (b) The expression of TNFSF4 in three cell types (fibroblast, LCLs, and T-cell) derived from umbilical cords of 75 Geneva GenCord individuals is shown. (c) The expression of TNFSF4 in three tissue types (adipose, LCLs, and skin) derived from a subset of ~160 MuTHER healthy female twins is shown. In MuTHER study, the eQTL analysis was done separately for each tissue. Within each tissue, twins from the same pair were separated by id in two samples analyzed independently. This separation resulted in the following sample size for LCL (L), skin (S), and fat (A), respectively: Twin 1 (74, 76, 79) and Twin 2 (82, 84, 87). SNP-gene association plot is not currently available to 856 healthy female twins of the MuTHER resource in the GENEVAR software. Symbols represent individual subjects. For comparison of continuous variables, two-tailed bivariate correlations and Spearman’s coefficient were calculated. Spearman’s rho (ρ), and nominal value are shown above each plot.
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