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BioMed Research International
Volume 2013 (2013), Article ID 598461, 17 pages
Review Article

Cell Mechanosensitivity: Mechanical Properties and Interaction with Gravitational Field

State Research Center of Russian Federation Institute of Biomedical Problems, Russian Academy of Sciences, 76-a, Khoroshevskoyoe shosse, Moscow 123007, Russia

Received 7 October 2012; Revised 17 November 2012; Accepted 27 November 2012

Academic Editor: Masamitsu Yamaguchi

Copyright © 2013 I. V. Ogneva. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper addressed the possible mechanisms of primary reception of a mechanical stimulus by different cells. Data concerning the stiffness of muscle and nonmuscle cells as measured by atomic force microscopy are provided. The changes in the mechanical properties of cells that occur under changed external mechanical tension are presented, and the initial stages of mechanical signal transduction are considered. The possible mechanism of perception of different external mechanical signals by cells is suggested.