Interleukin 1-β, Interleukin-1 Receptor Antagonist, and Interleukin 18 in Children with Acute Spontaneous Urticaria

Table 2

Serum levels of IL-1β, IL-1RA, and IL-18 in children with urticaria and healthy children.

Groups	Number	IL-1𝛽 (pg/mL)	IL-1RA (pg/mL)	IL-18 (pg/mL)
Single episode of acute urticaria
All children	39	1.3±0.8	889.1±205.3^∗	98.0±18.7^∗∗
Children with signs of infection	21	0.7±0.6	1129.8±676.0^#	102.0±47.8^##
Children without infection	18	1.6±0.8	608.3±512.0	93.1±71.3
Recurrent urticaria
All children	17	1.6±0.9	570.5±278.1	56.6±8.6
Children with signs of infection	5	0.8±0.2	512.7±372.2	54.8±16.4
Children without infection	12	1.9±2.1	594.6±242.5	56.9±19.3
Healthy controls	41	1.3±0.3	529.4±114.8	62.2±7.4

Data are shown as mean ± standard error. 𝑃 values from Mann-Whitney 𝑈 test.
∗All children with single episode of acute urticaria versus control group, 𝑃<0.004.
∗∗All children with single episode of acute urticaria versus control group and children with recurrent urticaria, 𝑃<0.0005.
#Patients with single episode of urticaria—children with signs of infection versus children without infection, 𝑃<0.01 and versus control group, 𝑃<0.0001.
##Patients with single episode of urticaria—children with signs of infection versus control group, 𝑃<0.00008.