Figure 9: Comparison between 12-month Mutants and 24-month Control rats (metabolic and physiological). Data shows comparison of metabolic and physiological parameters as compared to 24-month old Control rats. Panel (a) depicts fold change for body and pancreatic tissue weights, fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), tissue insulin, plasma and tissue thiobarbituric acid reacting species (TBARS), and islet size. Panel (b) depicts the fold change for insulin to glucagon ratio, inflammatory marker (CD11b, TNFα, and IL-6) fluorescent intensities, PDX-1 expression, apoptotic index, and ratio of basal to stimulated insulin secretory levels.