Obesity, Insulin Resistance, and Metabolic Syndrome: A Study in WNIN/Ob Rats from a Pancreatic Perspective
Table 1
Correlation matrix of anthropometric versus physiological parameters.
Body weights
Pancreas weights
HOMA-IR
QUICKI
FPG
FPI
Plasma TBARS
Tissue TBARS
Tissue insulin
Islet size
Apoptotic index
Body weights
Pearson correlation
1
Sig. (2-tailed)
.
Pancreas weights
Pearson correlation
0.700**
1
Sig. (2-tailed)
0.000
.
HOMA-IR
Pearson correlation
0.893**
0.501**
1
Sig. (2-tailed)
0.000
0.000
.
QUICKI
Pearson correlation
—
—
—
1
0.678**
0.372**
0.765**
Sig. (2-tailed)
0.000
0.006
0.000
.
FPG
Pearson correlation
0.339*
0.123
0.431**
—
1
0.397**
Sig. (2-tailed)
0.012
0.376
0.001
0.003
.
FPI
Pearson correlation
0.884**
0.494**
0.995**
—
0.408**
1
0.751**
Sig. (2-tailed)
0.000
0.000
0.000
0.000
0.002
.
Plasma TBARS
Pearson correlation
0.818**
0.837**
0.626**
—
0.294*
0.601**
1
0.519**
Sig. (2-tailed)
0.000
0.000
0.000
0.000
0.031
0.000
.
Tissue TBARS
Pearson correlation
0.917**
0.821**
0.669**
—
0.178
0.658**
0.874**
1
0.482**
Sig. (2-tailed)
0.000
0.000
0.000
0.000
0.199
0.000
0.000
.
Tissue insulin
Pearson correlation
0.812**
0.827**
0.710**
—
0.221
0.702**
0.778**
0.800**
1
0.572**
Sig. (2-tailed)
0.000
0.000
0.000
0.000
0.108
0.000
0.000
0.000
.
Islet size
Pearson correlation
0.765**
0.700**
0.749**
—
0.275*
0.725**
0.696**
0.699**
0.702**
1
0.549**
Sig. (2-tailed)
0.000
0.000
0.000
0.000
0.044
0.000
0.000
0.000
0.000
.
Apoptotic index
Pearson correlation
0.924**
0.554**
0.971**
—
0.367**
0.964**
0.657**
0.745**
0.733**
0.760**
1
0.736**
Sig. (2-tailed)
0.000
0.000
0.000
0.000
0.006
0.000
0.000
0.000
0.000
0.000
.
The table shows the correlation analysis between metabolic health parameters and physiological parameters and demonstrates a strong correlation of HOMA-IR and QUICKI with body weights, pancreas weights, plasma and tissue insulin levels, and plasma and tissue TBARS levels (). The table also shows the correlation analysis for other metabolic and physiological parameters (). FBG: fasting blood glucose, FPI: fasting plasma insulin, HOMA-IR: homeostasis model of assessment for insulin, QUICKI: quantitative insulin sensitivity check index, TBARS: thiobarbituric acid reacting species.
**Correlation is significant at the 0.01 level (2-tailed).
*Correlation is significant at the 0.05 level (2-tailed).