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BioMed Research International
Volume 2013, Article ID 620719, 21 pages
Review Article

Development of Microencapsulation Delivery System for Long-Term Preservation of Probiotics as Biotherapeutics Agent

1Department of Pharmaceutics, S.S.R. College of Pharmacy, Sayli-Silvassa Road, Sayli, Silvassa, Dora and Nagar Haveli 396230, India
2Hemchandracharya North Gujarat University, Patan, Gujarat 384265, India
3APMC College of Pharmaceutical Education and Research, Motipura, Himmatnagar, Sabarkantha 383001, India

Received 17 April 2013; Accepted 21 June 2013

Academic Editor: Salvatore Sauro

Copyright © 2013 Himanshu K. Solanki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The administration of probiotic bacteria for health benefit has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. The oral administration of most of the probiotics results in the lack of ability to survive in a high proportion of the harsh conditions of acidity and bile concentration commonly encountered in the gastrointestinal tract of humans. Providing probiotic living cells with a physical barrier against adverse environmental conditions is therefore an approach currently receiving considerable interest. Probiotic encapsulation technology has the potential to protect microorganisms and to deliver them into the gut. However, there are still many challenges to overcome with respect to the microencapsulation process and the conditions prevailing in the gut. This review focuses mainly on the methodological approach of probiotic encapsulation including biomaterials selection and choice of appropriate technology in detailed manner.