Figure 1: Phylogenetic informativeness profiles for the OrthoMaM data set. (a) Chronogram and the calibration points used to calculate site rates. Phylogenetic informativeness profiles over a 190 Myr period for (b) four amino acid sequence alignments and (c) four DNA sequence alignments, on the same time scale as in panel (a). Integration of the area below the profiles can provide a ranking of the predicted utility of genes for that epoch (here, the epoch encompassing the branch leading to primates). Integration results will be the largest for the genes that have the highest probability of exhibiting mutations during the given epoch that will not be obscured in subsequent branches. To quantitatively establish genes that will be most informative for the entire phylogeny, integrals over the whole time scale were calculated.