Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation

Table 1

hnRNPs in maintenance of stem cell self-renewal and development potency.

hnRNPs	Stem cell types	Functional context	Target gene	RNA/DNA interaction	Reference
hnRNP I/PTB	Embryonic stem cells	Proliferation; (G2/M progression)	CDK11(p58)	mRNA translation	[50–53]
hnRNP I/nPTB	Neuronal progenitor cells	Cell survival	(Not identified)	Splicing of exons	[54]
hnRNP A1/Hrp38	Germline stem cells	Staying in niche undifferentiated state	DE-cadherin	mRNA translation	[55, 56]
hnRNP A2/B1	Embryonic stem cells	Proliferation, pluripotency; (G1/S transition)	(Not identified)	(Not identified)	[57–59]
hnRNP U/AUF1	Embryonic stem cells	Cell pluripotency	OCT4	Transcription	[60]
EWS	Hematopoietic stem cells	Cell senescence	p16^INK4a	(Not identified)	[61, 62]
FUS	Hematopoietic stem cells	Cell survival, repopulation	(Not identified)	DNA repair	[63]