The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening

Figure 2

Histopathological analysis of paw injected with the Ehrlich tumor. The Ehrlich tumor cells (1 × 10⁶) or saline (25 μL) was injected subcutaneously into the hindpaws of the mice. Panel (a) indicates histological sections of normal paw that received saline, and panels (b)–(h) indicate the paw that received the Ehrlich tumor cells stained by hematoxylin/eosin. Arrows (1) indicate normal epithelium; (2) normal bone cartilage; (3) tumor cells; (4) destroyed bone cartilage; (5) extensive area of necrosis; (6) tumor cells with mitosis or atypical mitosis; (7) and tumor cells with atypical nucleus.

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