Managing Lymphoma with Non-FDG Radiotracers: Current Clinical and Preclinical Applications

Table 1

The clinically used radiopharmaceuticals for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging.

Modality	Radiopharmaceutical	Radionuclide	Half-life	Source	Uptake mechanism
PET	[^18F]Fluorodeoxyglucose	^18F	109 min	Cyclotron	Glucose transporter
	3′-Deoxy-3′-[^18F]fluorothymidine	^18F	109 min	Cyclotron	DNA replication
	^11C-methionine	^11C	20.4 min	Cyclotron	Amino acid transporter
SPECT	^67Ga-citrate	^67Ga	78.3 hr	Cyclotron	Transferrin receptor
	Thallium-201	^201Tl	73.0 hr	Cyclotron	Multiple factors; (i.e., Na-K-ATPase, non-energy-dependent cotransporter, etc.)
	^99mTc-sestamibi	^99mTc	6.0 hr	Generator	P-glycoprotein
	^99mTc-tetrofosmin	^99mTc	6.0 hr	Generator	P-glycoprotein
	^111In-labeled Octreotide	^111In	67.4 hr	Cyclotron	Somatostatin receptor