5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality
Figure 5
Acetaminophen (APAP) induces 5-LO-dependent neutrophil and macrophage recruitment. Neutrophil and macrophage recruitment to the liver was assessed by myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity determination in the liver 12 h after APAP (3 g/kg) or saline per oral treatment of WT and 5-LO−/− mice. Values are mean S.E.M., , representative of two separate experiments. * compared to saline-treated WT and 5-LO−/− mice and # compared to APAP-treated WT mice. One-way ANOVA was followed by Bonferroni’s multiple comparison test.
