Figure 8: 5-LO deficiency reduces acetaminophen (APAP)-induced increase of mRNA expression and increases transcription factor Nrf2 mRNA expression. The mRNA expression for (a) and Nrf2 (b) in the liver was assessed 12 h after APAP (3 g/kg) or saline per oral treatment of WT and 5-LO−/− mice. Values are mean S.E.M., , representative of two separate experiments. * compared to saline-treated WT and 5-LO−/− mice and # compared to APAP-treated WT mice. One-way ANOVA was followed by Bonferroni’s multiple comparison test.