5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality

Figure 8

5-LO deficiency reduces acetaminophen (APAP)-induced increase of gp91^phox mRNA expression and increases transcription factor Nrf2 mRNA expression. The mRNA expression for gp91^phox (a) and Nrf2 (b) in the liver was assessed 12 h after APAP (3 g/kg) or saline per oral treatment of WT and 5-LO^−/− mice. Values are mean ± S.E.M., 𝑛=4, representative of two separate experiments. *𝑃<0.05 compared to saline-treated WT and 5-LO^−/− mice and ^#𝑃<0.05 compared to APAP-treated WT mice. One-way ANOVA was followed by Bonferroni’s multiple comparison test.

(a)

(b)