Protective Efficacy of N-(2-Hydroxyphenyl) Acetamide against Adjuvant-Induced Arthritis in Rats

Table 3

Effect of NA-2 (5 mg/kg dose) on the time course of the development of inflammation as shown by increase in paw volume.

Experimental group

Mean ± SEM of paw volume (mL)/day of recording

00

02

04

06

08

10

12

14

16

18

20

22

Normal

3.9±0.5

3.9±0

3.9±0.72

3.8±0.72

3.7±0.67

3.8±0.75

3.8±0.73

4.0±0.74

4.0±0.63

4.0±0.61

4.0±0.51

4.0±0.53

Arthritic control

4.4±0.39

4.4±0.39

4.1±0.39

4.0±0.59

4.1±0.39

4.3±0.67

4.5±0.53

4.8±0.46

4.9±0.00

5.3±0.70

5.4±0.70

5.7±0.84

Arthritis + indomethacin (5 mg/kg)

4.1±0.54

4.1±0.52

4.0±0.67

4.0±0.66

4.0±0.67

4.1±0.00

3.9±0.0^##

3.8±0.00

4.0±0.00

4.0±0.00

3.9±0.00

3.8±0.00

Arthritis + NA-2 (5 mg/kg)

4.1±0.59

4.0±0.68

3.9±0.72

4.0±0.66

4.0±0.85

4.0±0.00

3.9±0.61^#

4.1±0.50

4.3±0.60

4.3±0.58

4.3±0.59

4.3±0.57

NA-2 only (5 mg/kg)

4.2±0.64

3.9±0.85

3.9±0.75

4.1±0.75

4.1±0.78

3.8±0.93

4.0±0.00

4.0±0.00

4.0±0.63

4.0±0.62

4.0±0.64

4.0±0.62

The value in the table represents the mean ± SEM of 12 animals/group. A significant increase in paw volume (𝑃 < 0.034) of arthritic animal compared to normal animals was observed from day 12 onward (^∗𝑃 < 0.00) until the end of experiment. Treatment with indomethacin decreases paw volume significantly (^##𝑃 < 0.05) from day 12 till the end. Treatment with NA-2 decreases paw volume of arthritic which significantly decreases from day 12 (^#𝑃 < 0.00) compared to control arthritic group.