CpG ODN and ISCOMATRIX Adjuvant: A Synergistic Adjuvant Combination Inducing Strong T-Cell IFN- Responses
Figure 3
BALB/c mice (/group) received a single IM immunization of 1 μg influenza. A haemagglutinin antigen (HA) either alone (none) or combined with CpG (10 μg), ISCOMATRIX (IMX) (1 μg), or CpG (10 μg) + ISCOMATRIX (1 μg). (a) each bar represents the group geometric mean (SEM) of the titer for HA-specific antibodies (anti-HA IgG) in plasma taken 4 wks after immunization. (b) each bar represents the group geometric mean (SEM) of the titer for HA-specific antibodies (anti-HA IgG) of IgG1 (open bars) or IgG2a (closed bars) in plasma taken 4 wks after immunization. Titers were defined as the highest plasma dilution resulting in an absorbance value two times that of nonimmune plasma with a cutoff value of 0.05. Representative data from one of two independent experiments is shown in each graph.
