Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells

Figure 10

Demonstration of the difference in proliferation potential between the stem cells and the transient amplifying cells. (a) Reproduced with permission from [24, Figure 2]. Difference in clonogenicity between the bulge cells and bulb cells of HFs. Note that the bulge (P3) contains 95% of the clonogenic keratinocytes, whereas the bulb (P1) contains 5%, and no clonogenic keratinocytes were detected in the rest of the portions (P2 and P4). (b) Reproduced with permission from [25, Figure 3C]. Difference in regeneration potential between the pedicle stump (stem cells) and the antler remnant (transient amplifying cells). Note that there was no difference in size between the 1st and the 4th set antlers regenerated from the pedicle stump; in contrast, the 4th set antler regenerated from the antler remnant was a small aborted one (arrow).