PSCA and Oct-4 Expression in the Benign and Malignant Lesions of Gallbladder: Implication for Carcinogenesis, Progression, and Prognosis of Gallbladder Adenocarcinoma
Table 2
The association of PSCA and Oct-4 expression with the clinicopathological characteristics of gallbladder adenocarcinoma.
Clinicopathological characteristics
Total no.
PSCA
Oct-4
Pos. nos. (%)
Pos. nos. (%)
Sex
Male
31
16 (51.6)
0.16
>0.05
17 (54.8)
0.01
>0.05
Female
77
43 (55.8)
43 (55.8)
Age (years)
≤45
24
14 (58.3)
0.17
>0.05
16 (66.7)
1.54
>0.05
>45
84
45 (53.6)
44 (52.4)
Differentiation*
Well
36
14 (38.8)
15.12
<0.01
13 (36.1)
13.31
<0.05
Moderately
31
16 (51.6)
18 (58.1)
Poorly
30
25 (83.3)
24 (80.0)
Mucinous A.
11
4 (36.4)
5 (45.5)
Tumor size (cm)
<2 cm
31
12 (38.7)
4.47
<0.05
10 (32.3)
9.56
<0.01
≥2 cm
77
47 (61.0)
50 (64.9)
Lymph node metastasis
No
49
19 (38.8)
8.04
<0.01
19 (38.8)
10.23
<0.01
Yes
59
40 (67.8)
41 (69.5)
T stages
T1
14
5 (35.7)
7.73
<0.05
4 (28.6)
17.24
<0.01
T2
35
15 (42.9)
13 (37.1)
T3
37
23 (62.2)
25 (67.6)
T4
22
16 (72.7)
18 (81.8)
Gallstones
No
50
27 (54.0)
0.01
>0.05
28 (56.0)
0.01
>0.05
Yes
58
32 (55.2)
32 (55.2)
Comparison between well-differentiated and moderately differentiated adenocarcinomas: = 1.09, ; = 3.23, .
*Comparison between wel-differentiated and poorly differentiated adenocarcinomas: = 7.29, ; = 6.98, < 0.01.
*Comparison between moderately differentiated and poorly differentiated adenocarcinoma: = 6.96, ; = 3.42, . Mucinous A.: mucinous adenocarcinoma.