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BioMed Research International
Volume 2013, Article ID 678456, 5 pages
Review Article

Role of Intracellular Ca2+ and Na+/Ca2+ Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury

1Division of Nephrology, Department of Internal Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China
2Division of Nephrology, Department of Internal Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China

Received 20 September 2013; Accepted 24 October 2013

Academic Editor: Michele Andreucci

Copyright © 2013 Dingping Yang and Dingwei Yang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca2+ overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca2+ channel (VDC) and Na+/Ca2+ exchanger (NCX) system are the main pathways of intracellular Ca2+ overload in pathological conditions. Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca2+ overload in the contrast media-induced renal tubular cell injury and renal hemodynamic disorder.