Protein Homeostasis Defects of Alanine-Glyoxylate Aminotransferase: New Therapeutic Strategies in Primary Hyperoxaluria Type I
Figure 2
The structure of AGT. (a) A ribbon representation of the dimeric AGT structure (PDB code 1H0C) colored to highlight the domain organization. The black squares represent the zoomed sections shown in panels 1(b) and 1(d). (b) A representation of the PLP binding site; G82 and H83 are in the vicinity of the cofactor. (c) A schematic representation of the possible “almost folded” AGT intermediates. (d) A representation of the AGT Pep5x intermolecular interface. The molecular surface representation of Pex5p is also displayed and colored in cyan. Those AGT residues interacting with Pep5x are displayed in a stick representation.
