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BioMed Research International
Volume 2013 (2013), Article ID 690835, 20 pages
Review Article

Understanding the Dengue Viruses and Progress towards Their Control

1“Pedro Kouri” Tropical Medicine Institute, WHO/PAHO Collaborating Centre for the Study of Dengue and Its Vector, Autopista Novia del Mediodía, Km 6 1/2, La Lisa, P.O. Box 601, Marianao 13, 11300 Havana, Cuba
2UMR190, Emergence des Pathologies Virales, Aix-Marseille Universite, Institut de Recherche pour le Développement, Ecole des Hautes Etudes en Santé Publique, Unité des Virus Emergents, Faculté de Médecine de Marseille, 27 Boulevard Jean Moulin, 13005 Marseille cedex 05, France
3CEH Wallingford, Maclean Building, Benson Lane, Crowmarsh Gifford, Oxfordshire OX10 8BB, UK

Received 13 March 2013; Accepted 8 May 2013

Academic Editor: Vittorio Sambri

Copyright © 2013 Rosmari Rodriguez-Roche and Ernest A. Gould. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Traditionally, the four dengue virus serotypes have been associated with fever, rash, and the more severe forms, haemorrhagic fever and shock syndrome. As our knowledge as well as understanding of these viruses increases, we now recognise not only that they are causing increasing numbers of human infections but also that they may cause neurological and other clinical complications, with sequelae or fatal consequences. In this review we attempt to highlight some of these features in the context of dengue virus pathogenesis. We also examine some of the efforts currently underway to control this “scourge” of the tropical and subtropical world.