Table 2: Advantages and disadvantages of various animal models for studying lung disease, particularly asthma [8, 9].


MouseIgE is the major anaphylactic antibodyDo not exhibit spontaneous AHR
Numerous inbred strainsLimited airway musculature
Numerous immunological reagentsLung anatomy differences
Small, relatively inexpensiveDo not easily demonstrate smooth muscle hyperplasia

Guinea pigThe lung is the primary organ of anaphylaxisIgG1 is the major anaphylactic antibody
Show early and late phase airway responsesShortage of inbred strains
Small, docile animals, inexpensiveFew species-specific reagents

RabbitPhylogenetically similar to humans
The lung is the major target organ
IgE is the major anaphylactic antibody
Large enough to study for lung mechanics
Demonstrate both early and late phase airway responses
Neonatal immunisation required for developing late phase airway response
Few species-specific reagents
Few transgenic species available
Gene sequences are not well mapped