N-Acetylcysteine Prevents Hypertension via Regulation of the ADMA-DDAH Pathway in Young Spontaneously Hypertensive Rats

Figure 5

Effects of NAC and GSH on renal DDAH activity. Posttranslational effect of N-acetylcysteine (NAC) and glutathione (GSH) on renal DDAH activity in WKY rats and SHR. WKY and SHR kidney homogenates were treated with different concentrations of GSH (0.25 mM, 2.5 mM) or NAC (0.1 mM, 10 mM). All measurements were made in triplicate. ^∗𝑃<0.05 versus untreated SHR; ^#𝑃<0.05 versus untreated WKY; ^$𝑃<0.05 SHR versus WKY with the same treatment.