- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 696343, 11 pages
Signal Transducer and Activator of Transcription Factor 6 Signaling Contributes to Control Host Lung Pathology but Favors Susceptibility against Toxocara canis Infection
1Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Avenue de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, MEX, Mexico City, DE, Mexico
2Laboratorio de Parasitología, Facultad de Estudios Superiores Cuautitlán, UNAM, 54714 Mexico City, DE, Mexico
3Laboratorio de Histopatología, Facultad de Estudios Superiores Cuautitlán, UNAM, 54714 Mexico City, DE, Mexico
4Carrera de Medicina, Facultad de Estudios Superiores Iztacala, UNAM, 54090 Mexico City, DE, Mexico
Received 10 August 2012; Accepted 29 October 2012
Academic Editor: Miriam Rodríguez-Sosa
Copyright © 2013 Berenice Faz-López et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- H. Avcioglu and I. Balkaya, “The relationship of public park accessibility to dogs to the presence of Toxocara species ova in the soil,” Vector-Borne and Zoonotic Diseases, vol. 11, no. 2, pp. 177–180, 2011.
- V. C. C. Dattoli, S. M. Freire, L. R. Mendonça, P. C. Santos, R. Meyer, and N. M. Alcantara-Neves, “Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre,” Tropical Medicine and International Health, vol. 16, no. 4, pp. 514–517, 2011.
- P. Congdon and P. Lloyd, “Toxocara infection in the United States: the relevance of poverty, geography and demography as risk factors, and implications for estimating county prevalence,” International Journal of Public Health, vol. 56, no. 1, pp. 15–24, 2011.
- E. Pinelli, T. Herremans, M. G. Harms, D. Hoek, and L. M. Kortbeek, “Toxocara and Ascaris seropositivity among patients suspected of visceral and ocular larva migrans in the Netherlands: trends from 1998 to 2009,” European Journal of Clinical Microbiology and Infectious Diseases, pp. 1–7, 2011.
- M. G. Walsh, “Toxocara infection and diminished lung function in a nationally representative sample from the United States population,” International Journal for Parasitology, vol. 41, no. 2, pp. 243–247, 2011.
- H. L. D. C. Amaral, G. L. Rassier, M. S. Pepe et al., “Presence of Toxocara canis eggs on the hair of dogs: a risk factor for Visceral Larva Migrans,” Veterinary Parasitology, vol. 174, no. 1-2, pp. 115–118, 2010.
- W. F. El-Tras, H. R. Holt, and A. A. Tayel, “Risk of Toxocara canis eggs in stray and domestic dog hair in Egypt,” Veterinary Parasitology, vol. 178, no. 3-4, pp. 319–323, 2011.
- R. A. Jabbour, S. S. Kanj, R. A. Sawaya, G. N. Awar, M. H. Hourani, and S. F. Atweh, “Toxocara canis myelitis: clinical features, magnetic resonance imaging (MRI) findings, and treatment outcome in 17 patients,” Medicine, vol. 90, no. 5, pp. 337–343, 2011.
- C. M. Hamilton, S. Brandes, C. V. Holland, and E. Pinelli, “Cytokine expression in the brains of Toxocara canis-infected mice,” Parasite Immunology, vol. 30, no. 3, pp. 181–185, 2008.
- F. D. Finkelman, T. Shea-Donohue, J. Goldhill et al., “Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models,” Annual Review of Immunology, vol. 15, pp. 505–533, 1997.
- W. C. Gause, J. F. Urban Jr, and M. J. Stadecker, “The immune response to parasitic helminths: insights from murine models,” Trends in Immunology, vol. 24, no. 5, pp. 269–277, 2003.
- M. Morimoto, A. Zhao, R. Sun et al., “IL-13 receptor α2 regulates the immune and functional response to Nippostrongylus brasiliensis infection,” Journal of Immunology, vol. 183, no. 3, pp. 1934–1939, 2009.
- J. F. Urban Jr, C. R. Maliszewski, K. B. Madden, I. M. Katona, and F. D. Finkelman, “IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice,” Journal of Immunology, vol. 154, no. 9, pp. 4675–4684, 1995.
- J. G. Perrigoue, F. A. Marshall, and D. Artis, “On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites,” Cellular Microbiology, vol. 10, no. 9, pp. 1757–1764, 2008.
- M. L. Knott, K. I. Matthaei, P. S. Foster, and L. A. Dent, “The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri,” Molecular Immunology, vol. 46, no. 13, pp. 2714–2722, 2009.
- F. D. Finkelman, T. Shea-Donohue, S. C. Morris et al., “Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites,” Immunological Reviews, vol. 201, pp. 139–155, 2004.
- J. F. Urban Jr, N. Noben-Trauth, D. D. Donaldson et al., “IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis,” Immunity, vol. 8, no. 2, pp. 255–264, 1998.
- P. Kolbeková, D. Větvička, J. Svoboda et al., “Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS,” Parasitology Research, vol. 109, no. 5, pp. 1267–1278, 2011.
- A. A. Othman, S. H. El-Shourbagy, and R. H. Soliman, “Kinetics of Foxp3-expressing regulatory cells in experimental Toxocara canis infection,” Experimental Parasitology, vol. 127, no. 2, pp. 454–459, 2011.
- L. I. Terrazas, R. Bojalil, T. Govezensky, and C. Larralde, “Shift from an early protective TH1-type immune response to a late permissive TH2-type response in murine cysticercosis (Taenia crassiceps),” Journal of Parasitology, vol. 84, no. 1, pp. 74–81, 1998.
- V. Fabre, D. P. Beiting, S. K. Bliss et al., “Eosinophil deficiency compromises parasite survival in chronic nematode infection,” Journal of Immunology, vol. 182, no. 3, pp. 1577–1583, 2009.
- M. Rodriguez-Sosa, J. R. David, R. Bojalil, A. R. Satoskar, and L. I. Terrazas, “Cutting edge: susceptibility to the larval stage of the helminth parasite Taenia crassiceps is mediated by Th2 response induced via STAT6 signaling,” Journal of Immunology, vol. 168, no. 7, pp. 3135–3139, 2002.
- H. Takeda, T. Tanaka, W. Shi et al., “Essential role of Stat6 in IL-4 signalling,” Nature, vol. 380, no. 6575, pp. 627–630, 1996.
- J. F. Urban Jr, L. Schopf, S. C. Morris et al., “Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism,” Journal of Immunology, vol. 164, no. 4, pp. 2046–2052, 2000.
- L. M. Stamm, A. Räisänen-Sokolowski, M. Okano, M. E. Russell, J. R. David, and A. R. Satoskar, “Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis,” Journal of Immunology, vol. 161, no. 11, pp. 6180–6188, 1998.
- R. L. Tarleton, M. J. Grusby, and L. Zhang, “Increased susceptibility of stat4-deficient and enhanced resistance in stat6-deficient mice to infection with Trypanosoma cruzi,” Journal of Immunology, vol. 165, no. 3, pp. 1520–1525, 2000.
- S. Fenoy, M. Rodero, E. Pons, C. Aguila, and C. Cuéllar, “Follow-up of antibody avidity in BALB/c mice infected with Toxocara canis,” Parasitology, vol. 135, no. 6, pp. 725–733, 2008.
- J. L. Reyes, A. F. Espinoza-Jiménez, M. I. González, L. Verdin, and L. I. Terrazas, “Taenia crassiceps infection abrogates experimental autoimmune encephalomyelitis,” Cellular Immunology, vol. 267, no. 2, pp. 77–87, 2011.
- W. I. Khan, B. A. Vallance, P. A. Blennerhassett et al., “Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice,” Infection and Immunity, vol. 69, no. 2, pp. 838–844, 2001.
- D. M. McKay and W. I. Khan, “STAT-6 is an absolute requirement for murine rejection of Hymenolepis diminuta,” Journal of Parasitology, vol. 89, no. 1, pp. 188–189, 2003.
- R. M. Anthony, J. F. Urban, F. Alem et al., “Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites,” Nature Medicine, vol. 12, no. 8, pp. 955–960, 2006.
- R. Bowcutt, L. V. Bell, M. Little et al., “Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris,” Parasite Immunology, vol. 33, no. 7, pp. 411–420, 2011.
- M. Becerra-Diaz, H. Valderrama-Carvajal, and L. I. Terrazas, “Signal transducers and activators of transcription (STAT) family members in helminth infections,” International Journal of Biological Sciences, vol. 7, no. 9, pp. 1371–1381, 2011.
- M. J. G. Johnston, A. Wang, M. E. D. Catarino et al., “Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice,” Infection and Immunity, vol. 78, no. 3, pp. 1364–1375, 2010.
- D. R. Herbert, T. Orekov, A. Roloson et al., “Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis,” Journal of Immunology, vol. 184, no. 11, pp. 6438–6446, 2010.
- D. R. Herbert, C. Hölscher, M. Mohrs et al., “Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology,” Immunity, vol. 20, no. 5, pp. 623–635, 2004.
- J. L. Reyes, C. A. Terrazas, J. Alonso-Trujillo, N. van Rooijen, A. R. Satoskar, and L. I. Terrazas, “Early removal of alternatively activated macrophages leads to Taenia crassiceps cysticercosis clearance in vivo,” International Journal for Parasitology, vol. 40, no. 6, pp. 731–742, 2010.
- J. L. Reyes and L. I. Terrazas, “The divergent roles of alternatively activated macrophages in helminthic infections,” Parasite Immunology, vol. 29, no. 12, pp. 609–619, 2007.
- J. E. Allen and R. M. Maizels, “Diversity and dialogue in immunity to helminths,” Nature Reviews Immunology, vol. 11, no. 6, pp. 375–388, 2011.
- S. J. Jenkins and J. E. Allen, “Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes,” Journal of Biomedicine & Biotechnology, vol. 2010, Article ID 262609, 14 pages, 2010.
- B. B. Mishra, U. M. Gundra, and J. M. Teale, “ mice exhibit decreased cells with alternatively activated macrophage phenotypes and enhanced disease severity in murine neurocysticercosis,” Journal of Neuroimmunology, vol. 232, no. 1-2, pp. 26–34, 2011.
- R. M. Maizels, J. P. Hewitson, and K. A. Smith, “Susceptibility and immunity to helminth parasites,” Current Opinion in Immunology, vol. 24, no. 4, pp. 459–466, 2012.